Pipeline
Pipeline Overview
CNTY-101: Our lead candidate targeting CD19 for relapsed, refractory B-cell lymphoma CNTY-101 is an allogeneic, iPSC-derived CAR-iNK cell therapy that has been engineered to express CD19 CAR, soluble IL-15, and an EGFR safety switch. CNTY-101 is currently being evaluated in the Phase 1 ELiPSE-1 trial (NCT05336409) for relapsed or refractory CD19 positive B-cell lymphomas.
CNTY-101: Our lead candidate targeting CD19 for relapsed, refractory B-cell lymphoma CNTY-101 is an allogeneic, iPSC-derived CAR-iNK cell therapy that has been engineered to express CD19 CAR, soluble IL-15, and an EGFR safety switch. CNTY-101 is currently being evaluated in the Phase 1 ELiPSE-1 trial (NCT05336409) for relapsed or refractory CD19 positive B-cell lymphomas.
CNTY-102: The Company has selected targets for CNTY-102, a CAR-iT product candidate, against CD19 and CD22 for relapsed, refractory B-cell lymphoma and other B-cell malignancies. CNTY-102 will simultaneously target CD19 and CD22, intended to increase depth and durability of response by eliminating the effect of CD19 antigen loss that has been observed as a factor limiting treatment durability, as well as targeting CD22, an independently regulated, ubiquitous and validated B-cell target. We have elected to develop CNTY-102 on our gamma delta iT platform.
CNTY-102: The Company has selected targets for CNTY-102, a CAR-iT product candidate, against CD19 and CD22 for relapsed, refractory B-cell lymphoma and other B-cell malignancies. CNTY-102 will simultaneously target CD19 and CD22, intended to increase depth and durability of response by eliminating the effect of CD19 antigen loss that has been observed as a factor limiting treatment durability, as well as targeting CD22, an independently regulated, ubiquitous and validated B-cell target. We have elected to develop CNTY-102 on our gamma delta iT platform.
CNTY-107: Our γδ iT product candidate for the treatment of solid tumors expressing Nectin-4.
CNTY-107: Our γδ iT product candidate for the treatment of solid tumors expressing Nectin-4.
CNTY-104: CAR-iT or CAR-iNK multi-specific candidate for acute myeloid leukemia Under our collaboration with Bristol Myers Squibb, CNTY-104 will utilize our multi-specific iNK or iT cells for the treatment of AML.
CNTY-104: CAR-iT or CAR-iNK multi-specific candidate for acute myeloid leukemia Under our collaboration with Bristol Myers Squibb, CNTY-104 will utilize our multi-specific iNK or iT cells for the treatment of AML.
CNTY-106: CAR-iT or CAR-iNK multi-specific candidate for multiple myeloma Under our collaboration with Bristol Myers Squibb, CNTY-106 will utilize our multi-specific iNK or iT cells for the treatment of multiple myeloma.
CNTY-106: CAR-iT or CAR-iNK multi-specific candidate for multiple myeloma Under our collaboration with Bristol Myers Squibb, CNTY-106 will utilize our multi-specific iNK or iT cells for the treatment of multiple myeloma.
Solid Tumors
Hematologic Tumors